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. 2022 Jan 19;8(3):eabj9815. doi: 10.1126/sciadv.abj9815

Fig. 7. PTX-COVID19-B protects hamster lungs from the pathology caused by SARS-CoV-2 challenge.

Fig. 7.

Lung tissues obtained from the hamsters in Fig. 6 were fixed in formalin and stained with hematoxylin and eosin. (A) Representative micrographs of the hamster lungs, showing extensive acute and mixed inflammatory cell infiltrates in bronchiole and alveoli in a control hamster receiving formulation buffer and paucity of inflammation in a vaccinated animal after challenged with SARS-CoV-2. Scale bars, 100 μm. (B) Pathology score of the hamster lungs. Shown are semiquantitative pathology scores of the hamster lungs. Each symbol represents one hamster (n = 4 per group per time point). The long horizontal lines indicate the means, and the short lines below and above the mean indicate the SEM. **P < 0.01 and ***P < 0.001 as determined by two-way ANOVA followed by Sidak’s multiple comparison test.