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. 2021 Dec 13;10:e68224. doi: 10.7554/eLife.68224

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© 2021, Zhang et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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Figure 6. — (A) Graphic summary describes the general organization of transcription factors (TFs) and post-transcriptional regulators in the specification of neuronal clusters at the whole-brain level. Effector genes describe the terminal features of whole-brain neuronal classification. Neuronal clusters with similar terminal features (named ‘sister clusters’) can share TF profiles (‘matched’, left), or exhibit distinct TF profiles (‘convergent’, middle). Besides, neuronal clusters with distinct effector gene profiles (terminal features) can share TFs profiles (‘divergent’, right), and in each pairs, two neuronal clusters are differentially marked by the expression of RNA-binding proteins (RBPs) at the post-transcriptional levels. Moreover, sister clusters with ‘convergent’ and ‘divergent’ patterns are glutamatergic/GABAergic neurons, whereas sister clusters with ‘matched’ pattern are neuromodulator-type neurons.