Table 2.

Multivariable logistic regression analysis evaluating the association between SGTF versus non-SGTF SARS-CoV-2 infection and hospitalisation, South Africa, Oct 1–Nov 30, 2021^* (n=11 255)

	Hospital admission†	Adjusted odds ratio (95% CI)	p value
SARS-CoV-2 variant (n=11 495)
SGTF	256/10 547 (2·4%)	0·2 (0·1–0·3)	<0·001
Non-SGTF	121/948 (12·8%)	1 (ref)	..
Age group (n=11 495)
<5 years	28/156 (17·9%)	9·3 (5·2–16·8)	<0·001
5–12 years	10/622 (1·6%)	0·8 (0·4–1·7)	0·52
13–18 years	13/669 (1·9%)	0·9 (0·4–1·7)	0·68
19–24 years	25/1115 (2·2%)	1 (ref)	..
25–39 years	161/4969 (3·2%)	1·5 (1·0–2·3)	0·069
40–59 years	77/3156 (2·4%)	1·0 (0·6–1·6)	0·94
≥60 years	68/808 (8·4%)	3·1 (1·9–5·0)	<0·001
Sex (n=11 404)
Male	144/5029 (2·9%)	1 (ref)	..
Female	235/6375 (3·7%)	1·3 (1·1–1·6)	0·016
Province (n=11 353)
Eastern Cape	0/9	..	..
Free State	9/122 (7·4%)	1·4 (0·6–3·6)	0·43
Gauteng	285/9507 (3·0%)	2·0 (1·0–3·7)	0·037
KwaZulu-Natal	40/534 (7·5%)	2·4 (1·2–4·7)	0·013
Limpopo	6/257 (2·3%)	1·7 (0·6–4·8)	0·33
Mpumalanga	4/241 (1·7%)	1·3 (0·4–4·1)	0·71
North West	11/274 (4·0%)	2·9 (1·2–6·9)	0·019
Northern Cape	4/108 (3·7%)	0·8 (0·2–2·4)	0·64
Western Cape	12/301 (4·0%)	1 (ref)	..
Health-care sector (n=11 495)
Public	159/3026 (5·3%)	1 (ref)	..
Private	223/8469 (2·6%)	0·8 (0·6–1·0)	0·024
Reinfection‡(n=11 495)
No	351/10 352 (3·4%)	1 (ref)	..
Yes	31/1143 (2·7%)	1·1 (0·7–1·6)	0·66

Data are n/N (%), unless otherwise specified. SGTF=S gene target failure.

^*Patients with COVID-19 followed up for hospital admission until Dec 21, 2021.

^†Admission to hospital from 7 days before to 21 days following diagnosis (date of specimen collection).

^‡Reinfection was defined by an individual having at least one positive SARS-CoV-2 test more than 90 days before the current positive SARS-CoV-2 test.