Table 2.
Statistics of drug combination databases, software tools and other related databases reviewed in this paper
| Database | Statistics | Website | Latest update | ||||
|---|---|---|---|---|---|---|---|
| Drugs/ compounds |
Combination experiments | Target proteins | Interactions | ||||
| Drug combination database | DrugComb_v1.5 [57] | 8397 | 739 964 | https://drugcomb.fimm.fi/ | March 2021 | ||
| DrugCombDB [59] | 5350 | 498 865 | http://drugcombdb.denglab.org/ | May 2019 | |||
| SYNERGxDB [61] | 1977 | 536 596 | https://www.synergxdb.ca/ | 2019 | |||
| NCI-ALMANAC [42] | 104 | 304 549 | https://dtp.cancer.gov/ncialmanac | December 2017 | |||
| O’Neil et al. study [62] | 38 | 22 737 | March 2016 | ||||
| ASDCD [63] | 135 | 548 | 1225 (DTI) | http://asdcd.amss.ac.cn/ | May 2018 | ||
| AZ-DREAM [34] | 118 | 11 576 | https://www.synapse.org/#!Synapse:syn4231880/wiki/235649 | June 2016 | |||
| DCDB_v2.0 [65] | 904 | 1813 |
http://www.cls.zju.edu.cn/dcdb/
(dose not respond now) |
2014 | |||
| TTD [66] | 37 316 | 119 | 3419 | 6975 (PPI) | http://db.idrblab.net/ttd/ | June 2020 | |
| DrugR+ [67] | http://www.drugr.ir (dose not respond now) | ||||||
| Software tools | SynergyFinder [68] | https://synergyfinder.fimm.fi | 2020 | ||||
| Synergy [71] | https://pypi.org/project/synergy | June 2021 | |||||
| CompuSyn [72] | https://www.combosyn.com/ | 2005 | |||||
| Combenefit [73] | https://sourceforge.net/projects/combenefit/ | 2016 | |||||
| Other related databases | DrugBank_v5.1.6 [138] | 13 570 | 5251 | 365 984 (DDI) | http://www.drugbank.ca/ | January 2021 | |
| Chemical checker [139] | 778 531 | https://chemicalchecker.org | May 2020 | ||||
| STITCH_v5.0 [140] | >500 000 | >9.6 × 106 | >1.6 × 109 (DTI) | http://stitch.embl.de/ | 2016 | ||
| KEGG [141–143] | 30 507 | https://www.kegg.jp/ | August 2021 | ||||
| SIDER_v4.1 [144] | 1430 | http://sideeffects.embl.de/ | October 2015 | ||||
| Offsides and Twosides_v0.1 [145] | 3394 | 63 000 | 5.7 × 106 (DDI: SE) | http://tatonettilab.org/offsides/ | November 2019 | ||
| PubChem [146] | 96 157 016 | 79 622 | https://pubchem.ncbi.nlm.nih.gov/ | 2019 | |||
| Uniprot [147] | >1.2 × 108 | https://www.uniprot.org/ | February 2020 | ||||
| SuperTarget [148] | 195 770 | 6219 | 332 828 (DTI) | http://insilico.charite.de/supertarget/index.php | 2011 | ||
| BioGRID_v3.5 [149] | 1 814 182 (PPI) | https://thebiogrid.org/ | May 2020 | ||||
| HPRD [150] | 30 047 | 41,327 (PPI) | http://www.hprd.org/ | 2010 | |||
| LINCS_v2.0 [151] | 41 847 | 1469 | http://www.lincsproject.org/LINCS/ | June 2020 | |||
| ChEMBL [152] | 1 961 462 | 13 382 | https://www.ebi.ac.uk/chembl/ | May 2020 | |||
| DTC [153] | 4276 | 1007 | 204 901 (DTI) | http://drugtargetcommons.fimm.fi | 2018 | ||
| TDR targets [154] | ~2 000 000 | ~5300 | http://tdrtargets.org/ | March 2021 | |||
| The IUPHAR/BPS Guide to PHARMACOLOGY [155] | 10 905 | 2989 | http://www.guidetopharmacology.org/ | ||||
| CancerDR [156] | 148 | 116 | https://webs.iiitd.edu.in/raghava/cancerdr/ | 2012 | |||
| BindingDB [157] | 995 797 | 8561 | 2 303 972 (DTI) | http://www.bindingdb.org/bind | July 2021 | ||
Note: DTI: drug/compound–target interaction. DDI: drug–drug interaction.
ASDCD: Antifungal synergistic drug combination database. DCDB: Drug combination database. TTD: Therapeutic target database. STITCH: Search Tool for Interacting Chemicals. KEGG: Kyoto Encyclopedia of Genes and Genomes. UniProt: Universal Protein. BioGRID: Biological General Repository for Interaction Datasets. HPRD: Human Protein Reference Database. LINCS: Library of Integrated Network-Based Cellular Signatures. DTC: Drug Target Commons.