Figure 3 .

Performance of circRNA detection methods on the simulated data set. A, Precision and recall of the circRNA detection methods (labels as in Figure 1), including CirComPara2 (CCP2; green dot), CirComPara (CCP1; light green), and CIRI-full (CIRFU; black); the dashed-line curves display plot areas for 0.85, 0.90, 0.95 and 0.98 F₁-scores. B, CircRNA detection methods’ performance upon application of filters from 2 to 10 minimum circRNA raw expression estimates (BJR: back-splice junction read counts); dashed-line curves delimit F₁-scores plot areas from 0.92 to 0.98 with 0.01 increase steps; method colours as in (A). CCP1 was not included because it gives normalized expression estimates that are not compatible with the filtering on BJR counts.