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. 2021 Sep 15;23(1):bbab380. doi: 10.1093/bib/bbab380

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© The Author(s) 2021. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Sequencing quality control. PCA on normalized binned counts of reads for samples belonging to (A) cohort 1 or (B) cohort 2. (C) PCA on joined cohorts. SNPW (sequencing results from nonpregnant women) samples were added as control. (D) PCA on cohort 1 with addition of three tests samples, two of them resulted from failed alignments to the reference genome and the third correspond to a maternal aneuploidy. Color code: cohort 1, gold; cohort 2, grey; samples from nonpregnant women (SNPW), black; test samples: failed alignments to the reference genome, red and maternal aneuploidy, green.