TABLE 2.

Summary of omadacycline MTS reproducibility results by organism group and isolate for all testing sites

Organism group (all-site and -isolate essential agreement)	Reproducibility strain no., species
		No. of results at 2-fold dilution differencea,b
		–2	–1	0	1	2
Gram Negative (270 of 270 results[100%])	R1, E. coli			27			0.5
	R2, E. coli			26	1		1
	R3, E. coli			26	1		2
	R4, E. coli		11	16			8
	R5, K. pneumoniae			14	13		1
	R6, K. pneumoniae		12	14	1		4
	R7, K. pneumoniae		8	19			8
	R8, E. cloacae		11	16			2
	R9, E. cloacae		5	22			2
	R10, E. cloacae		8	9			2
Gram Positive (257 of 270 results [95.2%])	R1, MSSA		10	15	2		0.25
	R5, MSSA		3	21	3		1
	R8, MRSA			12	8	7	0.12
	R10, MRSA		5	22			2
	R11, S. lugdunensis		6	21			0.12
	R12, S. lugdunensis		4	21	2		0.12
	R14, E. faecalis (VSE)		2	24	1		0.12
	R15, E. faecalis (VSE)			18	7	2	4
	R16, E. faecalis (VRE)		1	17	9		0.12
	R17, E. faecalis (VRE)			12	11	4	1
Fastidious HTM and MHA-SB (295 of 297 results [99.3%])	R1, S. pneumoniae		1	18	8		0.5
	R2, S. pneumoniae		6	21			0.12
	R3, S. pneumoniae		9	18			1
	R6, H. influenzae	1		24	2		2
	R7, H. influenzae		13	14			1
	R11, S. pyogenes			16	11		0.12
	R12, S. anginosus			19	8		0.5
	R14, S. constellatus		1	19	6	1	0.12
	R15, H. parainfluenzae			24	3		2
	R16, S. pyogenes		1	22	4		0.25
	R17, S. anginosus		12	15			0.12
Fastidious MH-F (266 of 270 results [98.5%])	R1, S. pneumoniae			20	7		0.5
	R2, S. pneumoniae		1	26			0.12
	R3, S. pneumoniae		2	24	1		1
	R6, H. influenzae		1	25	1		2
	R7, H. influenzae			21	6		0.5
	R11, S. pyogenes		3	24			0.25
	R12, S. anginosus			18	9		0.5
	R13, S. intermedius	4	8	15			0.03
	R14, S. constellatus		1	15	11		0.12
	R15, H. parainfluenzae		2	25			2

^aEssential agreement pertains to the shaded results, which are within ±1 dilution of the modal MIC.

^bThe 2-fold dilution difference is the difference between each MIC and the modal MIC for all results.