KEY RESOURCES TABLE

REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
p110αPI3K	Cell Signaling Technol	Cat# 4255; RRID: AB_65988
p110γPI3K	Cell Signaling Technol	Cat# 5405; RRID: AB_1904087
CD31	BD Biosciences	Cat# 557355; RRID: AB_396660
VEGFR2	Cell Signaling Technol	Cat# 9698; RRID: AB_11178792
β-actin	BD Biosciences	Cat# 612656; RRID: AB_2289199
Chemicals, peptides, and recombinant proteins
poly(lactide-co-glycolide) (PLGA, 55kDa)	PolySci Tech, Akina	Cat# AP121
poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide) (PLGA-PEG600Da)	Nanosoft Polymers	Cat#2753-55k-600 Custom
poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide) (PLGA-PEG5000Da)	PolySci Tech, AKina	Cat# AK026
Polyethyleneimine (MW25000Da)	Millipore Sigma	Cat#: 408727
Sugen 5416	Cayman Chemical	Cat# 13342
Coumarin-6	Millipore Sigma	Cat# 442631
Experimental models: Cell lines
Hepa-1c1c7	ATCC	Cat# CRL-2026
Experimental models: Organisms/strains
Mouse: C57BL/6J	The Jackson Laboratories	Cat# 000664 In house breeding
Oligonucleotides
See Table S1 for gRNA sequences targeting mouse Pik3cg and Vegfr2	Integrated DNA Technologies	Custom
See Table S2 for primer sequences For genome editing analysis	Integrated DNA Technologies	Custom
See Table S3 for primer sequences for gene expression analysis	Integrated DNA Technologies	Custom
Recombinant DNA
All-in-one CRISPRCAG plasmid DNA	(Ran et al., 2013)	RRID: Addgene_48138
CDH5 promoter	(Prandini et al., 2005)	N/A
FOXM1 cDNA	(Huang et al., 2016)	Gene bank: U74613.1
All-in-one CRISPRCDH5 plasmid DNA expressing Cas9 and Pik3cg gRNA	This work	N/A
All-in-one CRISPRCDH5 plasmid DNA expressing Cas9 and Vegfr2 gRNA	This work	N/A
All-in-one CRISPRCDH5 plasmid DNA expressing Pik3cg gRNA and Vegfr2 gRNA for double knockout	This work	N/A
All-in-one CRISPRCDH5 plasmid DNA expressing Pik3cg gRNA and FOXM1 transgene for Pik3cg knockout and overexpression of FOXM1 simultaneously	This work	N/A