Figure 5.

Targeting HSF1 enhance sensitivity of doxorubicin and gemcitabine in MES-SA and FU-MMT-1 cells. (a) Western blot was used to detect the HSF1 expression after knockdown in MES-SA and FU-MMT-1 cells. (b, c) Cell viability were detected when HSF1 knockdown combined with treatment with doxorubicin in MES-SA and FU-MMT-1 cells. (d, e) Cell viability were detected when HSF1 knockdown combined with treatment with gemcitabine in MES-SA and FU-MMT-1 cells. (f–i) Colony forming ability were detected when HSF1 knockdown combined with treatment with gemcitabine or doxorubicin in MES-SA and FU-MMT-1 cells (^∗ vs. control group, P < 0.05; ^# vs. gemcitabine 1 μM or doxorubicin 1 μM group, P < 0.05).