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Tumor acidic microenvironment accelerates the migration and invasion of pancreatic cancer cells. (a) Cell motility detected by wound healing assay. (b) Cell motility and invasion ability assessed by transwell assay. (c) The expression of MMP-2 and MMP-9 measured by western blot. Error bars, mean ± SD from three independent experiments. ∗∗P < 0.01; ∗∗∗P < 0.001.
