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Tumor acidic microenvironment regulates the function of mitochondria via miR-451a/MEF2D axis. Under acidic conditions, PANC-1 cells were transfected with miR-451a mimics, pc-MEF2D, and the corresponding control group. (a) The oxygen consumption rate. (b) JC-1 staining was used to detect MMP loss of PANC-1 cells. (c) DCFH staining was used to detect ROS generation of PANC-1 cells. Error bars, mean ± SD from three independent experiments. $P < 0.05, ##P < 0.01, and ∗∗∗P < 0.001.
