Table 1.
Clinical and phenotypical characteristics of COVID-19 patients based on obesity, hypertension and ACEI administration.
| Obesity |
HT |
HT + ACEI |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Variable | No (n = 103) | Yes (n = 51) | P | No (n = 99) | Yes (n = 66) | P | No (n = 17) | Yes (n = 49) | P |
| Age | 63.7 ± 11.5 | 61.4 ± 11.9 | 0.259 | 59.1 ± 11.2 | 68.4 ± 9.9 | <0.001 | 69.4 ± 9.0 | 68.0 ± 10.3 | 0.612 |
| Sex (F/M) | 36/67 | 18/33 | 0.967 | 39/60 | 17/49 | 0.070 | 5/12 | 12/37 | 0.689 |
| Days of admission | 3.90 ± 2.76 | 3.42 ± 2.53 | 0.307 | 3.76 ± 2.60 | 3.98 ± 2.87 | 0.616 | 4.31 ± 3.16 | 3.87 ± 2.79 | 0.599 |
| No ICU/No mortality | 88 (85.4) | 35 (68.6) | 0.014 | 80 (80.8) | 50 (75.8) | 0.437 | 13 (76.5) | 37 (75.5) | 0.937 |
| ICU/mortality | 15 (14.6) | 16 (31.4) | 19 (19.2) | 16 (24.2) | 4 (23.5) | 12 (24.5) | |||
| Glucose at admission (mg/dL) | 118.7 ± 48.6 | 145.2 ± 64.7 | 0.007 | 124.9 ± 56.8 | 137.5 ± 61.7 | 0.200 | 125.1 ± 65.7 | 141.7 ± 60.5 | 0.355 |
| Total cholesterol (mg/dL) | 138.1 ± 31.4 | 145.4 ± 34.2 | 0.270 | 144.5 ± 34.7 | 132.9 ± 25.8 | 0.053 | 133.4 ± 34.9 | 132.7 ± 23.2 | 0.942 |
| LDH (IU/L) | 346.1 ± 134.0 | 378.1 ± 148.8 | 0.097 | 352.3 ± 153.4 | 366.3 ± 117.6 | 0.539 | 387.0 ± 128.1 | 358.8 ± 114.1 | 0.402 |
| CRP (mg/L) | 120.4 ± 109.4 | 158.2 ± 205.6 | 0.073 | 118.1 ± 106.2 | 155.4 ± 186.2 | 0.055 | 159.5 ± 69.6 | 154.1 ± 210.5 | 0.923 |
| IL-6 (0–100 mg/L) | 74 (71.8) | 31 (60.8) | 0.083 | 70 (70.7) | 40 (60.6) | 0.089 | 10 (58.8) | 30 (61.2) | 0.861 |
| IL-6 (>100 mg/L) | 29 (28.2) | 20 (39.2) | 29 (29.3) | 26 (39.4) | 7 (41.2) | 19 (38.8) | |||
| SBP (mmHg) | 138.9 ± 21.3 | 137.7 ± 22.4 | 0.748 | 136.7 ± 20.4 | 139.6 ± 23.9 | 0.402 | 145.7 ± 19.3 | 137.5 ± 25.2 | 0.224 |
| DBP (mmHg) | 79.3 ± 14.2 | 79.0 ± 13.9 | 0.895 | 80.3 ± 13.4 | 77.3 ± 15.2 | 0.094 | 79.0 ± 10.9 | 76.7 ± 16.4 | 0.593 |
| D-dimer (μg/mL) | 1.86 ± 6.85 | 1.55 ± 2.01 | 0.757 | 1.93 ± 7.00 | 1.43 ± 1.78 | 0.580 | 1.28 ± 0.77 | 1.48 ± 2.03 | 0.683 |
| AST (IU/L) | 53.4 ± 35.2 | 46.9 ± 19.4 | 0.223 | 52.5 ± 33.0 | 48.9 ± 25.8 | 0.456 | 53.0 ± 28.1 | 47.5 ± 25.2 | 0.467 |
| ALT (IU/L) | 42.9 ± 34.4 | 37.7 ± 21.1 | 0.333 | 43.6 ± 32.3 | 35.9 ± 25.4 | 0.055 | 36.8 ± 21.9 | 35.6 ± 26.6 | 0.879 |
| AST:ALT ratio | 1.46 ± 0.84 | 1.40 ± 0.56 | 0.640 | 1.35 ± 0.45 | 1.61 ± 1.02 | 0.029 | 1.49 ± 0.31 | 1.64 ± 1.17 | 0.609 |
Values are expressed as means ± standard deviations. P values were calculated by Student's T-tests. Bold numbers indicate P value lower than 0.05. F: female; M: male; HT: hypertension; ACEI: Angiotensin Converting Enzyme Inhibitors; LDH: lactate dehydrogenase; IL-6: interleukin 6; CRP: C-reactive protein; SBP: systolic blood pressure; DBP: diastolic blood pressure; AST: aspartate aminotransferase; ALT: alanine transaminase.