Table 2.
Clinical and phenotypical characteristics of COVID-19 patients based on cut-offs of IL-6 and median values of LDH.
| All |
IL-6 |
LDH |
|||||
|---|---|---|---|---|---|---|---|
| Variable | n = 165 | 0–100 mg/L (n = 110) | >100 mg/L (n = 55) | P | <332.5 IU/L (n = 77) | ≥332.5 IU/L (n = 77) | P |
| Age | 62.8 ± 11.6 | 61.5 ± 11.3 | 65.3 ± 11.9 | 0.051 | 63.1 ± 12.3 | 63.1 ± 10.9 | 0.983 |
| Sex (F/M) | 56/109 | 38/72 | 18/37 | 0.816 | 29/48 | 23/54 | 0.307 |
| Days of admission | 3.85 ± 2.70 | 4.27 ± 2.76 | 2.96 ± 2.35 | 0.004 | 3.74 ± 2.57 | 3.88 ± 2.88 | 0.758 |
| No ICU/No mortality | 130 (78.8) | 101 (91.8) | 29 (52.7) | <0.001 | 61 (79.2) | 59 (76.6) | 0.698 |
| ICU/mortality | 35 (21.2) | 9 (8.2) | 26 (47.3) | 16 (20.8) | 18 (23.4) | ||
| Glucose at admission (mg/dL) | 130.2 ± 59.1 | 119.9 ± 42.7 | 148.1 ± 77.0 | 0.004 | 121.2 ± 53.7 | 138.4 ± 64.1 | 0.087 |
| Total cholesterol (mg/dL) | 140.1 ± 32.1 | 142.6 ± 31.3 | 135.3 ± 33.2 | 0.246 | 141.5 ± 30.5 | 135.2 ± 32.0 | 0.298 |
| LDH (IU/L) | 358.1 ± 139.4 | 362.4 ± 150.2 | 350.1 ± 117.6 | 0.603 | 253.2 ± 57.3 | 463.1 ± 116.2 | <0.001 |
| CRP (mg/L) | 132.8 ± 143.7 | 107.7 ± 73.9 | 182.1 ± 217.8 | 0.002 | 127.2 ± 193.9 | 150.0 ± 70.7 | 0.342 |
| SBP (mmHg) | 137.8 ± 21.9 | 137.2 ± 20.7 | 139.2 ± 24.2 | 0.578 | 136.4 ± 22.7 | 139.1 ± 21.2 | 0.439 |
| DBP (mmHg) | 79.1 ± 14.1 | 79.3 ± 14.0 | 78.6 ± 14.5 | 0.749 | 77.6 ± 14.4 | 80.6 ± 12.4 | 0.080 |
| D-dimer (μg/mL) | 1.71 ± 5.46 | 1.78 ± 6.58 | 1.60 ± 2.11 | 0.846 | 0.96 ± 0.98 | 2.53 ± 7.68 | 0.084 |
| AST (IU/L) | 51.1 ± 30.3 | 53.1 ± 34.4 | 47.2 ± 20.1 | 0.240 | 41.1 ± 23.3 | 59.7 ± 30.7 | <0.001 |
| ALT (IU/L) | 40.6 ± 29.9 | 45.0 ± 34.5 | 32.0 ± 15.0 | 0.009 | 35.0 ± 25.6 | 43.6 ± 30.3 | 0.059 |
| AST:ALT ratio | 1.45 ± 0.74 | 1.38 ± 0.83 | 1.58 ± 0.53 | 0.057 | 1.31 ± 0.39 | 1.63 ± 0.97 | 0.009 |
Values are expressed as means ± standard deviations. P values were calculated by Student's T-tests. Bold numbers indicate P value lower than 0.05. F: female; M: male; LDH: lactate dehydrogenase; IL-6: interleukin 6; CRP: C-reactive protein; SBP: systolic blood pressure; DBP: diastolic blood pressure; AST: aspartate aminotransferase; ALT: alanine transaminase.