TABLE 3.
Colistin and polymyxin disk diffusion QC results for E. coli ATCC 25922 and P. aeruginosa ATCC 27853 (120 to 200 observations)
| Antimicrobial disk and QC strain | No. of positive isolates at zone diam (mm) of:
|
% isolates in range
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | PIa | Proposedb | |
| Colistin | ||||||||||
| E. coli ATCC 25922 | 0 | 4a | 33b | 70b | 12b | 1b | 0 | 0 | 0.0 | 100.0 |
| P. aeruginosa ATCC 27853 | 8b | 36b | 70b | 6b | 0b | 0 | 0 | 0 | NDc | 100.0 |
| Polymyxin B | ||||||||||
| E. coli ATCC 25922 | 0 | 1a | 9b | 79b | 89b | 22b | 0 | 0 | 0.5 | 99.5 |
| P. aeruginosa ATCC 27853 | 0 | 0 | 3b | 35b | 90b | 64b | 7b | 1 | ND | 99.5 |
PI, package insert range. Current PI ranges were: for colistin, E. coli ATCC 25922 at 11 to 15 mm, and for polymyxin B, E. coli ATCC 25922 at 12 to 16 mm.
The proposed QC ranges from cited experiments were: for colistin, E. coli ATCC 25922 at 16 to 20 mm, and P. aeruginosa ATCC 27853 at 15 to 19 mm; for polymyxin B, E. coli ATCC 25922 at 17 to 20 mm, and for P. aeruginosa ATCC 27853 at 17 to 21 mm.
PI zone diameter ranges were not defined (ND) for P. aeruginosa ATCC 27853.