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. Author manuscript; available in PMC: 2022 Jan 20.
Published in final edited form as: J Mol Biol. 2020 Nov 20;433(6):166720. doi: 10.1016/j.jmb.2020.11.019

Figure 3.

Figure 3.

Young’s modulus varies across different chromatin units (a) Graphical representation how the Young’s modulus is obtained from single molecules such as nucleosomes. (b) Both for mononucleosomes and individual nucleosomes within arrays, CENP-A nucleosomes have a lower Young’s modulus than canonical H3 nucleosomes. Furthermore, CENP-A binding partner CENP-C rigidifies CENP-A nucleosomes. Interestingly, H3 nucleosomes extracted from cells had a larger Young’s modulus than in vitro reconstituted H3 nucleosomes. Data is from Melters et al. and Rakshit et al.58,57