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. 2022 Jan 5;601(7893):422–427. doi: 10.1038/s41586-021-04249-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a, Sample collection time (dashed lines) and delivery time (solid lines) for women with pre-eclampsia (purple and green) and controls (grey). Gradients illustrate timelines for developing pathophysiology and onset of clinical symptoms. b, Quantile–quantile plot of ranked Spearman P values for women with pre-eclampsia (cases) versus controls. P values were calculated from Spearman correlation on cohort-corrected data for each gene. The genes used in the model are labelled. The black dotted line represents the expectation. c, Receiver operating characteristic curve (mean and 95% confidence interval) for the logistic regression model for pre-eclampsia (n = 524). d, Kaplan–Meier curves of deliveries in test-positive and test-negative populations (n = 439), excluding spontaneous preterm deliveries.