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. 2022 Jan 5;601(7893):422–427. doi: 10.1038/s41586-021-04249-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — a-c, Maternal plasma transcriptome fractions for gene sets averaged across all samples in a given collection window. Error bars correspond to the 95% confidence interval around the mean. CPM, counts per million. N=93 for each timepoint and gene set. d-f, signal across all cohorts with longitudinal data. Linear fits of transcriptome fractions for all samples across corresponding gestational ages recorded at the collection times. The band around the solid line corresponds to the 95% CI. All slopes for the gestational age coefficient are distinct from 0 at a confidence level of 0.05. Cohort is indicated by color.