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. 2021 Dec 15;601(7893):404–409. doi: 10.1038/s41586-021-04237-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 8 — a, Dot plot showing gene expression markers of ventral inhibitory neuron clusters. The size of the dots indicates the percentage of cells expressing a specific marker gene. The colour of the dots represents the average expression level. EAC, central extended amygdala; Inhib, inhibitory; MGE, medial ganglionic eminence; OB, olfactory bulb; PN, projection neuron; SPN, spiny projection neuron. b, Spatial transcriptomic mapping showing localization of ventral inhibitory neuron clusters in the mouse brain. c, Schematic representing the workflow for the manual dissection of striatum, olfactory bulb (OB), and amygdala from P6-P8 brains injected with STICR^E14. d, UpSet plot displaying clonal intersections amongst and within neuronal clusters of striatum, OB and amygdala. Only dispersing clones are shown. Bar graph on top indicate the number of observed intersections. The total cell number per cluster is represented on the right bar plot. Intersections amongst striatum, OB and amygdala are coloured in green. The heatmap shows the Spearman distance between the log-normalized average cluster gene expression. The insets (top right) are UMAP plots of single cells from striatum, OB and amygdala datasets, with clusters coloured by cell class type. NP, neuronal precursor. e, Schematic of lineage divergence for ventral inhibitory neuron cell types.