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. 2021 Dec 15;601(7893):404–409. doi: 10.1038/s41586-021-04237-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 10 — Schematic illustrating different scenarios of how cellular diversity could arise in the brain. Different cell types could arise from specified or fate-restricted progenitor cells (a), or be born sequentially from a common pool of progenitor cells (b, left). Such lineage-dependent processes suggest that cell-intrinsic mechanisms or local cues at the mitotic progenitor level, determine the fate of newborn cells. As another option, lineage-independent mechanisms such as extracellular induction, activity-dependent processes, or stochastic regulation (b, right) could drive the differentiation into different subtypes. Lineage-dependent and independent mechanisms are not mutually exclusive. c) Convergence is the process by which similar cell states arise from different lineages.