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. 2021 Dec 15;601(7893):404–409. doi: 10.1038/s41586-021-04237-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a, UMAP plot of single cells from the forebrain coloured by cluster. b, Schematics of patterns of lineage convergence and divergence. c, Dendrograms representing cluster relationships based on transcriptomic similarity (left) and lineage coupling correlations (STICR^E14, right). In purple are examples of lineage convergence; in green are examples of lineage divergence. CGE, caudal ganglionic eminence; EAC, central extended amygdala; IN, interneuron; MGE, medial ganglionic eminence; NP, neuronal precursor; PN, projection neuron; VIP, vasoactive intestinal polypeptide. d, UpSet plot of selected intersections for STICR^E14. Only dispersing clones are shown. The bar graph at the top shows the number of observed intersections, and the bar graph on the right shows the number of cells per cluster. e, Schematic for lineage convergence of astrocyte clusters 3 and 12a. f, UpSet plot for selected ventral inhibitory neuron types in STICR^E14. The bar graph at the top shows the number of observed intersections, and the bar graph on the right shows the number of cells per cluster.