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. 2021 Dec 15;601(7893):404–409. doi: 10.1038/s41586-021-04237-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 1 — a, Barcode diversity extrapolations derived from sequencing ca. 30 million reads of a representative STICR plasmid library. Mean ± 95% CI. b, Images of whole mount brains injected with STICR. c, Representative FACS gating for negative control (matching non-injected brain) and STICR^E10. d, UMAP plot coloured and numbered for each unsupervised cluster. Each dot represents a single cell. e, UMAP plot coloured by cells with recovered transcriptome and cells with recovered transcriptome and lineage barcode. f, Examples of clones on UMAP plot. Sibling cell relationships represented by shapes (dot, square, star, cross, triangle). g, UMAP plot and bar graph showing the distribution of recovered cells, coloured by stage of injection. h, UMAP plot and bar graph showing the distribution of recovered cells, coloured by experimental replicate.