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. 2021 Dec 15;601(7893):404–409. doi: 10.1038/s41586-021-04237-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — a, Single-cell heatmap showing the normalised expression of the top-5 marker genes for cell classes. Bars are colour-coded based on key in Fig. 1d. b, Immunohistochemestry showing STICR^E10 viral labelling of excitatory (CTIP2/CUX1) and inhibitory (GABA) neurons, astrocytes (S100B), oligodendrocytes (Olig2) and microglia (Iba1). White arrowheads indicate co-labelled cells, empty arrowheads indicate negative cells. Scale bar: 100 μm (top), 30 μm (insets), 50 μm (bottom). Biological replicates, n = 2. c, Heatmap showing clonal distributions across cell classes for STICR^E10 (left) and STICR^E14 (right). Every horizontal line in the plot is a clone, with number of cells per clone indicated by colour. d, UpSet plots displaying clonal intersections between Astrocytes, Neurons, Oligodendrocyte Precursor Cells (OPCs), Neuronal precursors and Oligodentrocytes in STICR^E10 (top) and STICR^E14 (bottom). Bar graphs on top indicate the number of observed intersections. The bar graphs on the right depicts total cell number per cell class.