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. 2021 Nov 18;601(7893):410–414. doi: 10.1038/s41586-021-04231-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a, Designs of the CVnCoV and CV2CoV mRNA vaccine candidates. Both vaccines are based on CureVac’s RNActive platform and encode SARS-CoV-2 spike protein with di-proline mutations. The vaccines differ in their unique non-coding regions, as shown. b, Non-human primate vaccine study schema. Cynomolgus macaques were immunized intramuscularly (i.m.) on day (D) 0 with CVnCoV (n = 6) or CV2CoV (n = 6) mRNA vaccine or were designated as sham (n = 6). The animals were boosted at week 4 and were challenged at week (W) 8. Samples were collected weekly after immunization and on days 0, 1, 2, 4, 7 and 10 after challenge for immunological and virological assays. PP, K986P and V987P mutations; HSL, histone stem–loop.