Extended Data Fig. 6. Post-challenge binding and neutralizing antibody responses (6/group).
Negative control (sham) or animals vaccinated on d0 and d28 of the experiment with 12 µg of CVnCoV or CV2CoV as indicated were subjected to challenge infection using 1.0×105 TCID50 SARS-CoV-2 via intranasal (IN) and intratracheal (IT) routes. (a) Titers of RBD binding antibodies and (b) pseudovirus neutralizing antibodies against ancestral SARS-CoV-2 strain were evaluated before (week 8) and a week after challenge infection (week 9). Each dot represents an individual animal, bars depict the median and the dotted line shows limit of detection. Statistical analysis was performed using two-tailed nonparametric Mann-Whitney test. NAbs = neutralizing antibodies.