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. 2021 Mar 2;91(1):83–91. doi: 10.1038/s41390-021-01409-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Representative images from control and teratogen-treated fetal mice are presented. A normal diaphragm dissected from a control mouse is shown (a). Teratogen treatment was associated with the occurrence of diaphragm defects, characterized by a hole in the posterolateral region of the diaphragm (*; b). An image of a partially dissected fetus from a control mouse shows the diaphragm sitting atop the liver (Li, c). Teratogen treatment was associated with the protrusion of the fetal liver through the hole in the diaphragm (arrow; d). The left lung from a control (e) and teratogen-treated (f) fetus is also shown. Diaphragm defect severity was graded according to a system extrapolated from human CDH (g) and was used to generate a heat map of hernia occurrence in teratogen treated mice (h). The grade and sidedness of diaphragm defects is also presented (i). Scale bars: a–d = 1 mm, e, f = 500 µm.