Table 2.
Univariable and Multivariable Analysis on Factors Associated With Positive Serology to BNT162b2 Vaccine in LT Recipients According to Antibody Titers 3 Months After 2-dose Vaccination (Dependent Variable: Positive Serology)
| Characteristics | Univariable, OR (95% CI) | P value | Multivariable, OR (95% CI) | P value |
|---|---|---|---|---|
| Age, y (continuous) | 0.98 (0.95–0.99) | .016 | ||
| <40 | Ref | Ref | ||
| 40–65 | 0.09 (0.01–0.66) | .018 | 0.12 (0.02–0.99) | .049 |
| >65 | 0.09 (0.01–0.72) | .022 | 0.11 (0.01–0.86) | .036 |
| Male sex | 0.86 (0.52–1.43) | .568 | ||
| BMI, kg/m2 (continuous) | 1.03 (0.97–1.08) | .307 | ||
| <25 | ref | |||
| 25–30 | 0.93 (0.57–1.49) | .755 | ||
| ≥30 | 1.35 (0.71–2.56) | .36 | ||
| Smoke history, yes | 0.64 (0.39–1.04) | .069 | ||
| Indication to LT | ||||
| HCC | 192 (39.02) | .014 | 0.77 (0.46–1.28) | .327 |
| Advanced chronic liver disease | 300 (60.98) | .014 | Omitteda | |
| Etiology of liver disease | ||||
| Viral infection | 0.88 (0.52–1.48) | .634 | ||
| ALD | 0.88 (0.39–1.96) | .762 | ||
| NAFLD | 0.53 (1.12–2.25) | .388 | ||
| Autoimmune liver diseases | 1.13 (0.36–3.51) | .832 | ||
| Other | 2.10 (0.86–5.13) | .102 | ||
| History of re-transplantation | 1.07 (0.29–3.97) | .915 | ||
| History of rejection | 0.79 (0.48–1.31) | .366 | ||
| Time from transplantation, y | ||||
| <1 | Ref | Ref | ||
| 1–5 | 2.75 (0.80–9.45) | .108 | 2.33 (0.64–8.43) | .195 |
| 5–10 | 4.05 (1.15–14.29) | .03 | 3.53 (0.93–13.39) | .063 |
| >10 | 5.73 (1.75–18.75) | .004 | 4.55 (1.24–16.60) | .022 |
| Immunosuppressive drugs | ||||
| Calcineurin inhibitor | 0.98 (0.57–1.70) | .964 | ||
| Antimetabolite | 0.42 (0.27–0.66) | < .00 | 0.51 (0.28–0.93) | .029 |
| mTor inhibitor | 0.64 (0.40–1.03) | .069 | ||
| Single drug | Ref | |||
| Two or more drugs | 0.32 (0.20–0.51) | < .00 | 0.58 (0.31–1.03) | .082 |
| Steroids | 0.66 (0.29–1.50) | .322 | ||
| Comorbidities | ||||
| Cardiovascular disease | 0.54 (0.31–0.93) | .028 | 0.58 (0.32–1.03) | .065 |
| Diabetes mellitus | 0.87 (0.52–1.46) | .61 | ||
| Active cancer | 1.07 (0.29–3.97) | .915 | ||
| Previous cancer | 0.98 (0.52–1.84) | .958 | ||
| Chronic kidney disease | 0.90 (0.45–1.81) | .776 | ||
| Respiratory disease | 0.63 (0.15–2.58) | .528 | ||
| Two or more comorbidities | 0.89 (0.49–1.60) | .71 |
Note: Estimates were derived from multivariable logistic regression models adjusted for all the outcome variables. Only the variables found to be significant in the monovariate analysis were added in the multivariate.
Note: Boldface P values indicate statistical significance.
ALD, Alcoholic liver disease; BMI, body mass index; CI, confidence interval; HCC, hepatocellular carcinoma; LT, liver transplant; NAFLD, nonalcoholic fatty liver disease; OR, odds ratio.
a
Omitted because of collinearity