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. 2022 Jan 20;3(2):137–153.e3. doi: 10.1016/j.medj.2022.01.001

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© 2022 The Author(s)

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Antibody neutralization in relation to the serum and salivary spike IgG

All included samples are collected at day 35 from the beginning of vaccination.

(A) Correlation between anti-Spike serum antibodies detected by the quantitative test Elecsys Anti-SARS-CoV-2 S and the multiplex bead-based assay (Spike-f; n = 435).

(B–D) 120 samples were tested by PNT assay (B–D). For PNT, a low signal intensity indicates the blocking of Spike-ACE2 binding (y axis) and the data are used to correlate with the serum or salivary Spike-specific IgG levels (x axis). All correlations were tested by Spearman’s test, and rho coefficient and p value are reported in the plots. Each dot represents one sample, and the color code refers to indicated group. PNT, pseudoneutralization.