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Interaction of brain connectivity, neural plasticity and energy metabolism. We hypothesized that diabetes may lead to abnormalities in neuroplasticity and energy metabolism in the brain through multiple pathological pathways, ultimately leading to cognitive impairment that may reflect to MRI structural connectivity and functional connectivity, respectively. IDE, insulin degrading enzyme; AGEs, advanced glycation end products; DM, Diabetes mellitus; Aβ, amyloid beta.
