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. 2022 Jan 19;79(2):79. doi: 10.1007/s00018-021-04029-9

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — The Hippo/YAP signaling pathway regulates the ROS levels in cochlear HCs after neomycin injury. A Schematic diagram of drug addition in tissue culture (divided into four groups). B Immunofluorescence staining with Mito-SOX and Myosin7a in the middle turn of the cochlear basilar membrane after different treatments. C Quantification of the numbers of Mito-SOX + / Myosin7a + double-positive cells in (B). The numbers of Mito-SOX + / Myosin7a + double-positive cells were significantly increased in the neomycin-treated group compared with the control group. In addition, the neomycin-induced oxidative stress was significantly increased by VP treatment and decreased by XMU treatment. D The mRNA levels of redox-related genes were analyzed by qPCR in the neomycin-only group and the XMU-pretreatment group after neomycin injury. *p < 0.05, **p < 0.01, ***p < 0.001, n = 3. Scale bars = 20 µm