Table 2.

Clinical characteristics NBHS bacteremia episodes in relation to TTP

Characteristic	Episodes	TTP, median	TTP, mean	p value univariate3	p value multivariate4	Multiplication vs. reference level (exponent of beta)
All episodes	263 (100)	15 (12–21)	18
Age (years)				0.080	0.92	0.99
18–70	124 (47)	14 (12–20)	18
≥ 71	139 (53)	16 (13–22)	18
Sex				0.044	0.15	0.93
Male	155 (59)	16 (12–22)	19
Female	108 (41)	15 (12–19)	17
Charlson score				0.12	0.80	1.01
0–1	130 (49)	16 (13–22)	19
≥ 2	133 (51)	15 (12–21)	18
Site of acquisition				0.006	0.53	0.96
Community	146 (56)	17 (13–23)	20
Non-community	117 (44)	14 (12–20)	17
Infective endocarditis				0.51	0.54	0.95
Yes	28 (11)	15 (12–19)	17
No	235 (89)	15 (12–21)	18
NBHS group				< 0.001
S. bovis	19 (7.2)	10 (8.8–13)	12		0.006	0.75
S. mutans	7 (2.7)	22 (20–28)	26		0.002	1.66
S. sanguinis	32 (12)	16 (12–19)	18		0.27	1.10
S. mitis	105 (40)	14 (12–17)	15		5
S. salivarius	17 (6.5)	12 (11–13)	13		0.09	0.83
S. anginosus	83 (32)	21 (17–26)	24		<0.001	1.45
Neutropenia1				< 0.001	0.15	0.88
Yes	35 (13)	13 (11–16)	14
No	228 (87)	16 (13–22)	19
Other focal infection2				0.005	0.91	0.99
Yes	61 (23)	18 (13–24)	22
No	202 (77)	15 (12–20)	17

“All cases” are presented as numbers (%). Time to positivity (TTP) is presented as median hours with interquartile range (IQR). ¹Absolute neutrophil count < 0.5 × 10⁹/L at the time positive blood culture was drawn. ²Including osteomyelitis, spondylodiscitis, gastroinstestinal infection, urogenital infection, airway infection, and soft tissue infection. ³Univariate statistical analyses were performed using the Mann-WhitneyU test or the Kruskal-Wallis test. ⁴Statistical analysis performed via multivariate regression analysis. ⁵S. mitis indicated as baseline NBHS group in statistical analysis