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. 2022 Jan 19;12:978. doi: 10.1038/s41598-022-04929-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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A comparison of the WT SSM, IFM and PNM shape types within GENA348 mitochondrial subpopulations. (A) Distribution of the shape type within the GENA348 mitochondrial population. (B) A comparison of the WT and GENA348 shape types reveals that GENA348 SSM and IFM have more mitochondria with tubular projections compared to the WT and that there are more irregularly shaped IFM. (C) Examples of 3D reconstructions of GENA348 mitochondria with tubular projections. Scale bar = 1 µm. (D) Tubular projections from WT mitochondria are the same length independent of mitochondrial subtype whereas GENA348 SSM have longer projections compared to IFM and PNM. (E) The width of the WT tubular projections are the same across each mitochondrial group whereas in the GENA348 SSM are wider than the IFM and PNM (raw data points show to spread of measurements, n = 3). (F) A comparison of the projection parameters (raw data points shown, n = 3) identified the GENA348 SSM as being longer and wider than WT SSM. There was no difference in IFM and PNM dimensions between the WT and GENA348 (not shown). Projection dimensions are reported in Table 2.