Table 1.
Summary of echocardiography and physiological parameters in GENA348 mice compared to WT (6 months of age).
| Echocardiography | WT n = 15 |
GENA348 n = 8 |
P value |
|---|---|---|---|
| dLVD (mm) | 4.57 ± 0.06 | 4.43 ± 0.09 | 0.24 |
| sLVD (mm) | 3.47 ± 0.08 | 3.27 ± 0.09 | 0.15 |
| dIVS (mm) | 0.98 ± 0.03 | 1.03 ± 0.03 | 0.37 |
| sIVS (mm) | 1.41 ± 0.03 | 1.42 ± 0.06 | 0.82 |
| dPW (mm) | 1.06 ± 0.03 | 1.28 ± 0.06 | 0.002 |
| sPW (mm) | 1.31 ± 0.03 | 1.54 ± 0.07 | 0.0006 |
| HR (b/min) | 469 ± 8.0 | 456 ± 4.0 | 0.34 |
| LV mass/(mg) | 194 ± 7.0 | 222 ± 11 | 0.05 |
| RWT | 0.45 ± 0.01 | 0.53 ± 0.02 | 0.02 |
| EF% | 55 ± 1.90 | 59.5 ± 2.1 | 0.22 |
| FS% | 24.2 ± 1.2 | 26. 3 ± 1.3 | 0.28 |
| E:A | 2.65 ± 0.20 | 1.84 ± 0.19 | 0.03 |
| IVRT | 15.2 ± 1.13 | 20.5 ± 0.37 | 0.004 |
| Physiological | WT | GENA348 | P value |
|---|---|---|---|
| Blood glucose (fasted) (mmol/l) |
7.56 ± 0.39 (n = 5) |
9.583 ± 0.38 (n = 6) |
0.005 |
| Insulin (µg/ml) |
2.26 ± 0.12 (n = 5) |
2.07 ± 0.10 (n = 6) |
0.09 |
| HW/TL (mg/mm) |
6.56 ± 0.17 (n = 15) |
7.37 ± 0.17 (n = 13) |
0.0022 |
| LW (mg) |
161.10 ± 4.54 (n = 15) |
169.20 ± 4.60 (n = 13) |
0.2233 |
dLVD diastolic diameter, sLVD systolic diameter, dIVS diastolic intraventricular septum, sIVS systolic intraventricular septum, dPW diastolic posterior wall, sPW systolic posterior wall, HR heart rate, EF ejection fraction, FS fractional shortening, LV mass left ventricular mass, RWT relative wall thickness, E:A early to late ventricular filling ratio, IVRT isovolumetric relaxation time, HW heart weight, TL tibia length, LW lung weight. Data are presented as the mean ± SEM (P < 0.05 considered as a significant change).