Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Stopping rules for the three-stage design.
| Stage | Rule for efficacy stopping | Rule for futility stopping | Rule for continuing to next stage |
|---|---|---|---|
| 1 (10 participants) | >6 responders | <=2 responders | 3–6 responders |
| 2 (15 participants) | >8 responders | <=5 responders | 6–8 responders |
| 3 (20 participants) | >9 responders | <=9 responders | NA |
