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. 2022 Jan 19;12:980. doi: 10.1038/s41598-021-03836-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The interaction network and correlation between SFs and AS events. (A) The red dots indicate down-regulation, and the green dots indicate up-regulation. The blue triangles indicate SFs. The green lines represent AS events, which were positively correlated with the expressions of SFs, while red lines indicate negative correlations. (B) The correlation analysis was performed using Pearson t test. MSI1 could positively regulate -13336-AP (r = 0.6579, P < 0.0001) and negatively

regulate TACC2TACC2-13333-AP (r = − 0.6554, P < 0.0001).