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. 2022 Jan 19;12:1015. doi: 10.1038/s41598-022-04799-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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TEM images showing type 2 erythrophores from red spots. (A) A low magnification image of the area between the dermis and epidermis (on the left). (B) Type 2 erythrophores are the only pigment cells present in this skin area. (C–E) Ultrastructure of type 2 erythrophores, including erythrosomes (red arrows), carotenoid vesicles (red arrowheads). (F) Fibroblasts or fibroblast-like cells communicate with the extracellular space via prominent caveolae (black arrowheads) and are well connected with each other as well with type 2 erythrophores via desmosomes (yellow arrowheads),. bl basal lamina, Co collagen fibres, Ep epidermis, Er2 type 2 erythrophore, GER granular endoplasmic reticulum, Nu nucleus. Scale bars: 2 μm (A); 4 μm (B); 600 nm (C,D); 1 μm (E); 400 nm (F).