Figure 4.

AFB bacilli were most abundant in category 6 granulomas in both rhesus and cynomolgus macaques. Representative images of AFB staining and multinucleated giant cells ZN (inserts HE). AFB were most abundant in category 6 granulomas in both species (A, B). In RM, AFB were frequently seen grouped together whereas AFB in CM were more often seen singularly within the necrotic core. MNGCs were identified in both species (C, D) with 12wpc category 6 granulomas having the highest number. RM on average had a higher proportion of MNGCs. AFBs were noticed within MNGCs in both species, although not frequently (E, F). Bars in micrograph = 200µm. Representative images from 2 slides per animal at each time point (week 4 & 12 = 4 RM & 4 CM).