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. 2021 Nov 2;126(2):247–258. doi: 10.1038/s41416-021-01599-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Correlation between DDIR score and tumour-infiltrating lymphocytes (TILs). An increasing percentage of stromal TILs correlates with increasing DDIR score. Dotted line shows threshold for DDIR negative/positive cut-off (r = 0.3386, P = 0.0213, Spearman correlation, 46 evaluable cases). b DDIR-positive tumours had significantly increased lymphocytic infiltration at baseline compared to tumours classified as DDIR negative. (*P = 0.0144, unpaired t test, 46 evaluable cases). c Percentage stromal TILs at baseline according to response to NACT using RCB score. No significant difference in TILs was identified in tumours with RCB 0 or 1 (median 10%) compared to RCB 2 or 3 (median 5%) responders. (P = 0.123, unpaired t test, 46 evaluable cases). d (i) Response to NACT was associated with reduced TILs at resection compared to baseline. (P = 0.0072, unpaired t test, 15 paired samples). (ii) No significant difference in TILs between baseline and resection was seen in non-responding tumours, with a non-significant increase noted following three cycles of FEC. (P = 0.0792, unpaired t test, 22 paired samples).