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. 2021 Nov 2;126(2):247–258. doi: 10.1038/s41416-021-01599-0

Fig. 4. T-cell/macrophage expression and PD-L1/macrophage expression across breast cancer subtypes, by DDIR status.

Fig. 4

From top to bottom, luminal, HER2-positive and triple-negative breast cancer (TNBC) cases are illustrated and have been stained for cytokeratin (red), CD68 macrophages (yellow), CD8 T cells (white) and PD-L1 immune-checkpoint protein (green) expression. DDIR-positive cases are shown on the left and DDIR-negative cases on the right, illustrating higher CD68 and CD8 expression in DDIR-positive tumours, and co-localisation of PD-L1 and CD68 in DDIR-positive cases. All images are shown at ×4 magnification.