Figure 1.

Three million HeLa cells were injected subcutaneously into the flank of eleven 11 athymic nude female mice. The animals were separated into three groups: vehicle (n = 3), IR alone (n = 4), and M3814 + IR (n = 4). Treatment started 26 days after injection. The vehicle group received M3814 vehicle control by oral gavage once daily 5 days per week for weeks one to three. The IR alone group received 2 Gy radiation 5 days per week for week one. The combined M3814 + IR group received peposertib (M38814) 50 mg/kg by oral gavage once daily 5 days per week for weeks 1–3, and 2 Gy radiation 5 days per week for week one. Radiation was administered 60 min after M3814 drug administration.