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. 2022 Jan 19;12:974. doi: 10.1038/s41598-021-04618-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Xenograft experiments were performed with HeLa cell lines in athymic nude mice. Treatment was started 26 days after HeLa cell implantation. Three groups were investigated: vehicle alone (n = 3), IR alone (n = 4), or M3814 in combination with IR (n = 4). Tumor volume was measured twice weekly. (A) shows mean tumor volume of each group over the course of treatment. (B) shows average tumor volume at treatment endpoint (day 47), t tests were done to compare the treatment groups. (C) shows mouse weights during the course of treatment.