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. 2022 Jan 19;12:957. doi: 10.1038/s41598-022-05021-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Selection of target genes. (A) The genes that closely related to intervertebral disc degeneration screened in weighted correlation network analysis (Gene set A) and co-expression network (Gene set B). (B) Pearson correlation analysis between CD63 and IL1, ECM, COL2A1, TIMP, MMP and ADAMTS. (C) Significant relatedness of CD63 with TIMP1, TIMP2, TIMP3 and COL2A1.