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. 2022 Jan 19;12:1022. doi: 10.1038/s41598-022-05012-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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ER stress increased the miRNA expression in differentiating neurospheres. (a) Differential expression analysis of miRNAs in DMSO-treated cells (n = 3) and thapsigargin-treated cells (n = 3) was performed using edgeR. The y-axis indicates the expression ratio [log₂ (fold change)], and the x-axis indicates the average of expression [log (CPM)]. Solid red circle: upregulated miRNA; solid blue circle: downregulated miRNA. FDR < 0.05. (b) Model of the effect of long-term obesity on neural maturation during AHN.