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. 2022 Jan 19;8:1. doi: 10.1038/s41540-021-00210-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — ( indicates control culture; indicates culture treated with 25 ppm AgNP). a The extracellular folic acid concentrations increased on exposure to AgNPs. This increase could be an outcome of the oxidative stress induced in the organism, which in turn impact folate related metabolic pathways. b MTT analysis of HCT116 treated with bacterial supernatants from cultures exposed to silver nanoparticles and control. Reduction in viability was observed for cells treated with 9th h supernatants (p-value = 0.0031), the time point corresponding to maximum concentration. Values are expressed as mean ± SD, n = 3.

Inline graphic — ( indicates control culture; indicates culture treated with 25 ppm AgNP). a The extracellular folic acid concentrations increased on exposure to AgNPs. This increase could be an outcome of the oxidative stress induced in the organism, which in turn impact folate related metabolic pathways. b MTT analysis of HCT116 treated with bacterial supernatants from cultures exposed to silver nanoparticles and control. Reduction in viability was observed for cells treated with 9th h supernatants (p-value = 0.0031), the time point corresponding to maximum concentration. Values are expressed as mean ± SD, n = 3.