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. 2022 Jan 19;8:1. doi: 10.1038/s41540-021-00210-9

Table 2.

Host and host–microbe model novel predictions.

Reactions Comments
CRC specific model predictions
3, 4-Dihydroxymandelaldehyde:NADP + Oxidoreductase (EC:1.2.1.5) This enzyme catalyzes the synthesis of DHMA (catechol), a potent anti-oxidant, that inhibits lung cancer42. But its role in CRC metabolism/treatment has not been investigated. CRC metabolic model showed increased flux through the related enzyme-catalyzed reaction.
CRC-microbe integrated model predictions
Sn-Glycerol-3-Phosphate: (Acceptor) 2-Oxidoreductase (EC:1.1.3.21) This enzyme catalyzes the OXPHOS pathway reaction, which is reported to be rewired in various cancers like prostate and ovarian39. The CRC–microbe (when compared with CRC alone) metabolic model captured the switch from glycolysis to the OXPHOS pathway (increased flux through the related enzyme-catalyzed reaction).
Catechol O-Methyltransferase (EC:2.1.1.6) This enzyme catalyzes the synthesis of S-Adenosyl-homocysteine (SAH) from S-Adenosyl-methionine (SAM) and higher levels of SAH have been implicated in cardiovascular and chronic kidney diseases45. The related enzyme-catalyzed reaction showed increased flux in the CRC-microbe model.