TABLE 3.
Ferroptosis differentially expressed genes of IPF.
| Gene | log2FC | p-value | FDR | Gene title |
|---|---|---|---|---|
| Downregulated genes | ||||
| NOS2 | −77 | 3.05E-20 | 1.53E-19 | Nitric Oxide synthase 2 |
| HBA1 | −1.67 | 0.00011 | 0.000110,466 | Hemoglobin Subunit Alpha 1 |
| CAV1 | −1.40 | 1.12E-23 | 1.12E-22 | Caveolin 1 |
| EPAS1 | −1.29 | 4.83E-14 | 9.66E-14 | Endothelial PAS Domain Protein 1 |
| CDO1 | −1.23 | 1.79E-13 | 2.99E-13 | Cysteine dioxygenase Type 1 |
| JUN | −1.13 | 1.48E-10 | 1.97E-10 | Jun Proto-Oncogene, AP-1 Transcription Factor Subunit |
| SLC2A12 | −1.11 | 5.51E-16 | 1.38E-15 | Solute Carrier Family 2 Member 12 |
| Upregulated genes | ||||
| CDKN2A | 1.04 | 8.00E-17 | 2.67E-16 | Cyclin Dependent kinase Inhibitor 2 A |
| SLC7A5 | 1.05 | 3.79E-10 | 4.74E-10 | Solute Carrier Family 7 Member 5 |
| GPX2 | 1.06 | 4.27E-11 | 6.10E-11 | Glutathione peroxidase 2 |
| CA9 | 1.09 | 7.13E-09 | 7.92E-09 | Carbonic anhydrase 9 |
| SLC2A1 | 1.20 | 6.24E-13 | 9.60E-13 | Solute Carrier Family 2 Member 1 |
| RGS4 | 1.29 | 1.47E-06 | 1.55E-06 | Regulator Of G Protein Signaling 4 |
| GDF15 | 1.50 | 1.39E-16 | 3.97E-16 | Growth Differentiation Factor 15 |
| ALOX15 | 1.52 | 5.11E-10 | 6.01E-10 | Arachidonate 15-Lipoxygenase |
| HNF4A | 1.64 | 1.93E-18 | 7.72E-18 | Hepatocyte Nuclear Factor 4 Alpha |
| PROM2 | 2.24 | 2.80E-20 | 1.53E-19 | Prominin 2 |
| TP63 | 2.26 | 2.23E-15 | 4.95E-15 | Tumor Protein P63 |
| DRD5 | 2.80 | 2.86E-26 | 5.73E-25 | Dopamine Receptor D5 |
| NGB | 3.61 | 7.58E-14 | 1.38E-13 | Neuroglobin |
FDR: false discovery rate.