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. 2022 Jan 6;12:801097. doi: 10.3389/fneur.2021.801097

Figure 2.

Figure 2

Predicted slopes illustrate the two-way interaction between ILT2/PD-1 positive and negative CD8+CD57+ T-cells and brain-PAD [mean ± 1 standard deviation (SD)] on disability score. (A) A higher CD8+CD57+ T-cell frequency (x-axis) and a higher brain-PAD (prediction lines) predicted a higher EDSS-score (y-axis) significantly, p = 0.04. (B) A higher CD8+CD57+ILT2+PD-1+ T-cell frequency (x-axis) and a higher brain-PAD (prediction lines) predicted a higher EDSS-score (y-axis) significantly, p < 0.001. (C) A higher CD8+CD57+ILT2+PD-1+ T-cell frequency (x-axis) and a higher brain-PAD (predicted lines) predicted a higher 25-FWT-score (y-axis) significantly, p < 0.001. (D) A non-significant interaction effect of CD8+CD57+ILT2+PD-1− T-cells (x-axis) and brain-PAD (prediction lines) on EDSS-score (y-axis), p = 0.052. (E) A non-significant interaction effect of CD8+CD57+ILT2−PD-1+ T-cells (x-axis) and brain-PAD (prediction lines) on EDSS-score (y-axis), p = 0.191. (F) A non-significant interaction effect of CD8+CD57+ILT2−PD-1− T-cells (x-axis) and brain-PAD (prediction lines) on EDSS-score (y-axis), p = 0.323. PD-1, programmed death 1; ILT2, immunoglobulin-like transcript 2; EDSS, expanded disability scale status; 25-FWT, 25-food walk test; brainPAD, brain predicted age difference (brain-PAD). Brain-PAD is divided in three subgroups based on the mean value of brain-PAD ± 1SD represented by a striped line (mean brain-PAD −1SD); a dotted line (mean brain-PAD); and a continuous line (mean brain-PAD + 1 SD). The shaded areas represent the 95% confidence intervals.