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. 2022 Jan 6;11:799566. doi: 10.3389/fonc.2021.799566

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Copyright © 2022 Liu, Liang, Long, Zhu, Hou, Wu and Luo

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Impact of ZCCHC17 on survival in HCC patients from different cohorts. (A–C) The expression of ZCCHC17 was significantly related to patients’ OS (P= 0.004), PFS (P=0.0032) and DSS (P=0.003) in TCGA; (D) High methylation level of cg08734125 is relevant to the patient’s better OS (P=0.011) in TCGA; (E, F) Low methylation level of cg25469212 is relevant to the patient’s worse OS(P=0.027) and PFS (P= 0.049) in TCGA; (G) The poor OS correlated with high ZCCHC17 expression in ICGC(P=0.006); (H) High expression of ZCCHC17 indicates a poor OS in the validation cohort. (P= 0.0015).