Table 1.
Correlations between AA detection and clinicopathological parameters in UTUC.
| Parameter | Category | Upper Urinary Tract Urothelial Carcinoma | ||||
|---|---|---|---|---|---|---|
| Case No. | AA detection (adducts/e8 DNA bases) | p-value | ||||
| ND | < 30 | ≥ 30 | ||||
| Gender | Male | 21 | 10 | 8 | 3 | 0.955 |
| Female | 38 | 19 | 13 | 6 | ||
| Interval from renal transplantation to primary diagnosis of UTUC (months) | < 48 | 21 | 10 | 5 | 6 | 0.035* |
| ≥ 48, < 96 | 15 | 10 | 3 | 2 | ||
| ≥ 96 | 23 | 9 | 13 | 1 | ||
| Age (years) | < 60 | 44 | 24 | 12 | 8 | 0.068 |
| ≥ 60 | 15 | 5 | 9 | 1 | ||
| Hepatitis B virus (HBV) | Negative | 32 | 18 | 11 | 3 | 0.136 |
| Positive | 13 | 4 | 5 | 4 | ||
| Hepatitis C virus (HCV) | Negative | 45 | 23 | 15 | 7 | 0.422 |
| Positive | 5 | 4 | 1 | 0 | ||
| Sirolimus (Rapamycin) | No use | 26 | 8 | 13 | 5 | 0.046* |
| Yes | 35 | 22 | 9 | 4 | ||
| Cyclosporin A (CsA) | No use | 25 | 10 | 11 | 4 | 0.47 |
| Yes | 36 | 20 | 11 | 5 | ||
| Tacrolimus (FK506) | No use | 13 | 9 | 3 | 1 | 0.262 |
| Yes | 48 | 21 | 19 | 8 | ||
| Mycophenolate Mofetil (Cellcept) | No use | 22 | 11 | 8 | 3 | 0.983 |
| Yes | 39 | 19 | 14 | 6 | ||
| Renal pelvis tumor stage | Ta | 6 | 4 | 2 | 0 | 0.058 |
| T1 | 9 | 4 | 1 | 4 | ||
| T2-T4 | 19 | 14 | 4 | 1 | ||
| Ureter tumor stage | Ta | 10 | 4 | 4 | 2 | 0.928 |
| T1 | 9 | 5 | 3 | 1 | ||
| T2-T4 | 18 | 10 | 5 | 3 | ||
| Papillary | Absent | 16 | 4 | 9 | 3 | 0.072 |
| Present | 45 | 26 | 13 | 6 | ||
| High grade | Absent | 2 | 0 | 2 | 0 | 0.16 |
| Present | 59 | 30 | 20 | 9 | ||
| Lymphovascular invasion | Absent | 50 | 23 | 18 | 9 | 0.279 |
| Present | 11 | 7 | 4 | 0 | ||
| Squamous differentiation | Absent | 46 | 21 | 18 | 7 | 0.61 |
| Present | 15 | 9 | 4 | 2 | ||
| Carcinoma in situ | Absent | 20 | 10 | 6 | 4 | 0.65 |
| Present | 41 | 20 | 16 | 5 | ||
| Tumor necrosis | Absent | 44 | 18 | 17 | 9 | 0.051 |
| Present | 17 | 12 | 5 | 0 | ||
| Anemia (men < 13.5 g/dL, women < 12 g/dL) | Absent | 28 | 12 | 13 | 3 | 0.26 |
| Present | 30 | 16 | 8 | 6 | ||
| Neutrophil−lymphocyte ratio (NLR) | < 2 | 11 | 7 | 1 | 3 | 0.19 |
| ≥ 2, < 5 | 19 | 11 | 7 | 1 | ||
| ≥ 5 | 14 | 8 | 2 | 4 | ||
| Body mass index (BMI) | < 24 | 38 | 21 | 11 | 6 | 0.079 |
| ≥ 24 | 19 | 5 | 11 | 3 | ||
ND, not detected; *, statistically significant.
The bold values are equal to statistically significant values.