Table 4.
Correlations between AA detection and WES analysis.
| AA Detection (Adducts/e8 DNA Bases) | Tumor Content (%) | WES (Normal) | WES (Tumor) | WES (Tumor) | ||
|---|---|---|---|---|---|---|
| Nondriver TMB(Mutations/Mb) | Driver TMB(Mutations/Mb) | Nondriver TMB(Mutations/Mb) | Driver TMB(Mutations/Mb) | Driver genes | ||
| ND | 80 | 6.6 | 12.4 | 42.3 | 44.9 | ERCC2//JAK2//TBL1XR1//ATRX//COL5A1//SPTAN1//PTPDC1//PTPRD//SOX17//KEL//PIK3CG// EEF1A1//PIM1//HLA-B//NSD1//FBXW7//PDGFRA//PLXNB2//NF2//CASP8//PPM1D//KANSL1// BRCA1//NF1//NCOR1//TP53//CDH1//KMT2D//CHD4//CTNND1// MUC6//BTG2//EPHA2// |
| 16.5 | 25 | 4.8 | 0 | 23.9 | 41.6 | KMT2B//KMT2A//FLNA//STAG2//ZCCHC12//ATRX//AR//DMD//CDKN2A//CNBD1//FGFR1//KM T2C//HLA-B//MSH3//RFC1//NSD2//PLXNB2//CACNA1A//CREB3L3//AXIN2//KRT222//CDK12// NF1//TP53//ZFHX3//FLT3//MUC6//ELF3//MACF1//MTOR// |
| 7.1 | 50 | 6.8 | 15.7 | 34.3 | 39.3 | MSH6//KMT2A//SMARCA1//ATRX//USP9X//DMD//LEMD2//PIK3R1//PDGFRA//EP300//ASXL1// PCBP1//ARHGAP35//ZFHX3//NUP93//CHD8//KMT2D//INPPL1//MUC6//SPTA1//JAK1//THRAP3// ARID1A// |
| ND | 50 | 6.1 | 9 | 58.2 | 73 | VHL//KMT2A//STAG2//ATRX//ZMYM3//ABL1//SPTAN1//PTPRD//HGF//RAC1//MAP3K1//FAT1// POLQ//PBRM1//SCAF4//CUL3//ZFP36L2//CIC//CACNA1A//CD70//NF1//TP53//NUP93//CREBBP// TSC2//MGA//ATXN3//DACH1//BRCA2//ZMYM2//KMT2D//CHD4//MUC6//PTEN//RET//NUP133// BTG2//PTPRC//CSDE1//MACF1//ARID1A//EPHA2// |
| 25.9 | 60 | 6 | 3.4 | 80.7 | 58.4 | TAF1//ERBB3//TBL1XR1//ZMYM3//AMER1//RBM10//BCOR//DMD//RPS6KA3//PTPRD//KMT2C //HGF//GABRA6//FAT1//PIK3CA//RUNX1//FOXA2//ERBB4//PCBP1//XPO1//EPAS1//SOS1//ALK// APOB//CEBPA//CACNA1A//SMAD4//CDK12//CREBBP//RNF111//MGA//TRAF3//ZFP36L1//MAX //KMT2D//MUC6//RET//PTPRC//MACF1//MTOR// |
| 37.9 | 40 | 7 | 5.6 | 51.9 | 68.5 | MYH9//PRKAR1A//AMER1//HUWE1//DMD//COL5A1//TLR4//PTPRD//PIK3CG//GTF2I//EGFR//P MS2//CARD11//UNCX//ESR1//HLA-B//HLA-A//APC//NIPBL//ALB//RFC1//POLQ//SCAF4// ZNF133//KIF1A//ERBB4//APOB//EEF2//SMAD2//AXIN2//BRCA1//TP53//ZFHX3//NUP93//MAX// DACH1//LATS2//KMT2D//ATF7IP//CHD4//MUC6//SPTA1//NOTCH2//ARID1A//EPHA2//MTOR// |
| 17.4 | 40 | 3.7 | 6.7 | 47.9 | 50.6 | MYH9//DIAPH2//ATRX//AMER1//HUWE1//SMC1A//BCOR//COL5A1//SPTAN1//PTPRD//KMT2C //HGF//PIK3R1//FAT1//FBXW7//PBRM1//PLXNB2//SMARCB1//CUL3//APOB//SMAD2//SPOP//TP 53//CBFB//BRD7//TSC2//DICER1//CHD8//FLT3//KMT2D//ATM//RRAS2//MUC6//NUP133//ARID1A// |
ND, not detected; WES, whole exome sequencing; TMB, tumor mutation burden.