Figure 1.

X-MAID mice exhibit systemic inflammation ameliorated by lymphocyte deletion. WT or X-MAID male mice at 3-4 weeks old were measured for (A) body weight and (B) spleen weight. (C) The ratio of spleen to body weight was calculated. (D, E) H&E stains of sections from liver and lung of the indicated mouse strains, all at 3-4 weeks of age. Scale bars = 600μm. Note the granulocytic infiltration in X-MAID tissues, which is absent in tissues from X-MAID/RagKO mice. Data in (A–C) represent means ± StDev, with each point representing an individual mouse. Statistics were calculated using a Student’s t test, *p < 0.05, **p < 0.01, ****p < 0.0001.